The Most Nutritious Foods for Brain Health
A practical breakfast, lunch, and dinner guide using nutrient-dense proteins, healthy fats, and high-fiber carbohydrates.
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A Daily Guide to Better Brain Health for MCI and Early Dementia
A clear, step-by-step daily plan to support brain health and make life easier for people with mild cognitive impairment or early dementia.
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Farmed Fish and Shrimp: The Public Health Trade-Offs of Modern Aquaculture
Aquaculture carries the highest antimicrobial use intensity of any food-animal sector (164.8 mg/kg). What the evidence shows about resistance, residues, and pathogens in farmed fish and shrimp, and why the answer is choosing seafood carefully, not avoiding it.
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Creatine and Cognition in APOE ε4 Carriers: What the Evidence Actually Shows
No randomized trial has tested creatine in mild cognitive impairment, and the only Alzheimer study is a 20-person uncontrolled pilot using 20 g/day. What that means for APOE ε4 carriers — and where the small memory signal in healthy older adults really stands.
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Why Do Some APOE4 Carriers Never Develop Dementia?
Some APOE ε4 carriers reach old age with Alzheimer’s pathology in the brain and their thinking intact. What separates them is partly genetic, partly the absence of other brain diseases, and partly not what you have been told.
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I Have Two Copies of APOE4. Am I Going to Get Alzheimer’s?
Two copies of APOE ε4 makes Alzheimer’s biology in the brain close to universal with age. It does not make dementia universal. What the population data actually show about whether, and when.
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I Have APOE4. What Do I Do Now?
US POINTER found the same benefit for ε4 carriers as non-carriers (P=.95 for interaction). The MIND diet trial was negative. ACHIEVE was null overall. And the one omega-3 signal in Alzheimer’s trial data appeared only in ε4 non-carriers. A neurologist and ε4 carrier grades the evidence behind each recommendation — including the trials that did not work.
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Navigating Pre-Death Grief: Managing the Emotional Toll of Dementia Caregiving
Pre-death grief affects up to 71% of dementia caregivers and can exceed the grief felt after death. Evidence-based strategies — mindfulness, CBT, support groups, respite, and palliative care integration — that help caregivers navigate this ambiguous loss.
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APOE ε2, ε3, and ε4: How Two Amino Acid Substitutions Produce Three Different Clinical Phenotypes
LDL cholesterol rises linearly across APOE genotype, but coronary risk does not follow it. Bennet et al. (JAMA 2007; n=86,067) found a 44 mg/dL spread between the genotype extremes — and a coronary odds ratio in ε4 carriers of just 1.06 (95% CI 0.99–1.13). Three separate risk quantities are routinely quoted interchangeably in clinic, and only one of them belongs in a disclosure conversation.
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APOE 2, 3, and 4: What the Three Versions of This Gene Actually Do
Three versions of one gene, separated by two amino acids — and why that small difference sends Alzheimer’s risk in three different directions.