The Most Nutritious Foods for Brain Health
A practical breakfast, lunch, and dinner guide using nutrient-dense proteins, healthy fats, and high-fiber carbohydrates.
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Diet and APOE4 | Literature Reviews | Non-physician and family education | Physician or non-physician clinician | Premium
The ε4/ε4 Carriers Who Do Not Develop Alzheimer’s: Resistance and Resilience
A minority of APOE ε4 homozygotes reach advanced age without dementia. This review examines the distinction between resistance to amyloid pathology and resilience despite it, the protective variants and mechanisms implicated to date, and what these exceptional cases do — and do not — establish about modifiable risk in ε4/ε4 carriers.
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What’s Good for the Heart Really Is Good for the Brain — But Know Your Genotype
Cardiovascular risk factors are among the most consistently modifiable contributors to dementia risk, but the magnitude of benefit is not uniform across APOE genotypes. A physician’s guide to lipid management, blood pressure, and vascular optimization with the genotype-stratified evidence foregrounded.
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DHA and Brain Health: A Guide for APOE ε4 Carriers
Timing matters more than dose. Omega-3 DHA appears most useful for APOE ε4 carriers who start well before any memory symptoms — the largest trial in people who already had Alzheimer’s dementia found no cognitive benefit in ε4 carriers. The form matters too: fatty fish and roe deliver DHA by a route into the brain that ordinary fish oil capsules largely miss.
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APOE ε4 Carriers and Meat
Dietary meat intake and cognitive outcomes in APOE ε4 carriers, and what the observational data can and cannot establish.
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Intermittent Fasting: A Patient Guide
What intermittent fasting has been shown to do for brain aging, what remains mechanistic only, and who should not attempt it.