Change Your Brain Every Day (Amen, 2023): A Critical Appraisal for Clinicians Advising APOE ε4 Carriers
Amen’s daily reader recommends a lifestyle framework and a nine-supplement regimen in the same register. Only one survives comparison with the randomized evidence. US POINTER (n=2,111) found structured lifestyle intervention worked regardless of ε4 status; PreventE4 (n=365, 24 months) raised CSF DHA 17% with no cognitive or volumetric benefit. What a clinician should endorse, and what the reader cannot distinguish from within the text, is the appraisal.